Biotechnology

OpenAI and Top Investors Back Valthos with US$30M to Advance AI-Driven Biodefense

Reimagining biodefense at the intersection of AI, biology and urgency.

Updated

November 27, 2025 3:26 PM

Through computational tools, Valthos analyzes biological data to design adaptive solutions against emerging threats. PHOTO: VALTHOS

Valthos has raised US$30 million in seed funding, led by the OpenAI Startup Fund, Lux Capital and Founders Fund, to advance its mission of building next-generation biodefense systems.

The company’s work comes at a time when biotechnology is evolving at an unprecedented pace. Biotechnology is moving at record speed. These new tools can lead to life-changing medical discoveries, but they also bring the risk of dangerous biological agents being developed faster than ever.  

“The issue at the core of biodefense is asymmetry”, said Kathleen McMahon, co-founder of Valthos. “It’s easier to make a pathogen than a cure. We’re building tools to help experts at the frontlines of biodefense move as fast as the threats they face”. The gap Valthos aims to close is between the rapid rise of biological threats and the slower pace of developing cures. Therefore, the company is developing AI systems that can rapidly analyze biological sequences and significantly shorten the time needed to design medical countermeasures.

“In this new world, the only way forward is to be faster. So we set out to build a new tech stack for biodefense”, said Tess van Stekelenburg, co-founder of Valthos. “This software infrastructure strengthens biodefense today and lays the groundwork for the adaptive, precision therapeutics of tomorrow”.

The company was founded by van Stekelenburg, a partner at Lux Capital and McMahon, the former head of Palantir’s Life Sciences division. Together, they’ve built a multidisciplinary team of experts from Palantir, DeepMind, Stanford’s Arc Institute and MIT’s Broad Institute, bringing together deep experience in software engineering, machine learning and biotechnology.

“Technology is moving fast. An industrial ecosystem of builders, companies and solutions further democratizes AI to provide broad resilience, and ensures the U.S. continues to lead as AI increasingly powers everything around us. As AI and biotech rapidly advance, biodefense is one of the new industry verticals that helps maximize the benefits and minimize the risks”, said Jason Kwon, OpenAI’s Chief Strategy Officer. “Valthos is pushing the frontier of protection and defense in one of the most strategic intersections of multiple world-changing technologies, and with the team to do it”.

Looking ahead, Valthos plans to expand its engineering team and scale its software infrastructure for both government and commercial partners — moving closer to its goal of enabling faster, smarter and more adaptive biodefense capabilities.

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AI

What Happens When AI Writes the Wrong References?

HKU professor apologizes after PhD student’s AI-assisted paper cites fabricated sources.

Updated

November 28, 2025 4:18 PM

The University of Hong Kong in Pok Fu Lam, Hong Kong Island. PHOTO: ADOBE STOCK

It’s no surprise that artificial intelligence, while remarkably capable, can also go astray—spinning convincing but entirely fabricated narratives. From politics to academia, AI’s “hallucinations” have repeatedly shown how powerful technology can go off-script when left unchecked.

Take Grok-2, for instance. In July 2024, the chatbot misled users about ballot deadlines in several U.S. states, just days after President Joe Biden dropped his re-election bid against former President Donald Trump. A year earlier, a U.S. lawyer found himself in court for relying on ChatGPT to draft a legal brief—only to discover that the AI tool had invented entire cases, citations and judicial opinions. And now, the academic world has its own cautionary tale.

Recently, a journal paper from the Department of Social Work and Social Administration at the University of Hong Kong was found to contain fabricated citations—sources apparently created by AI. The paper, titled “Forty Years of Fertility Transition in Hong Kong,” analyzed the decline in Hong Kong’s fertility rate over the past four decades. Authored by doctoral student Yiming Bai, along with Yip Siu-fai, Vice Dean of the Faculty of Social Sciences and other university officials, the study identified falling marriage rates as a key driver behind the city’s shrinking birth rate. The authors recommended structural reforms to make Hong Kong’s social and work environment more family-friendly.

But the credibility of the paper came into question when inconsistencies surfaced among its references. Out of 61 cited works, some included DOI (Digital Object Identifier) links that led to dead ends, displaying “DOI Not Found.” Others claimed to originate from academic journals, yet searches yielded no such publications.

Speaking to HK01, Yip acknowledged that his student had used AI tools to organize the citations but failed to verify the accuracy of the generated references. “As the corresponding author, I bear responsibility”, Yip said, apologizing for the damage caused to the University of Hong Kong and the journal’s reputation. He clarified that the paper itself had undergone two rounds of verification and that its content was not fabricated—only the citations had been mishandled.

Yip has since contacted the journal’s editor, who accepted his explanation and agreed to re-upload a corrected version in the coming days. A formal notice addressing the issue will also be released. Yip said he would personally review each citation “piece by piece” to ensure no errors remain.

As for the student involved, Yip described her as a diligent and high-performing researcher who made an honest mistake in her first attempt at using AI for academic assistance. Rather than penalize her, Yip chose a more constructive approach, urging her to take a course on how to use AI tools responsibly in academic research.

Ultimately, in an age where generative AI can produce everything from essays to legal arguments, there are two lessons to take away from this episode. First, AI is a powerful assistant, but only that. The final judgment must always rest with us. No matter how seamless the output seems, cross-checking and verifying information remain essential. Second, as AI becomes integral to academic and professional life, institutions must equip students and employees with the skills to use it responsibly. Training and mentorship are no longer optional; they’re the foundation for using AI to enhance, not undermine, human work.

Because in this age of intelligent machines, staying relevant isn’t about replacing human judgment with AI, it’s about learning how to work alongside it.