A closer look at how machine intelligence is helping doctors see cancer in an entirely new light.
Updated
January 8, 2026 6:33 PM
Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
Artificial intelligence is beginning to change how scientists understand cancer at the cellular level. In a new collaboration, Bio-Techne Corporation, a global life sciences tools provider, and Nucleai, an AI company specializing in spatial biology for precision medicine, have unveiled data from the SECOMBIT clinical trial that could reshape how doctors predict cancer treatment outcomes. The results, presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting, highlight how AI-powered analysis of tumor environments can reveal which patients are more likely to benefit from specific therapies.
Led in collaboration with Professor Paolo Ascierto of the University of Napoli Federico II and Istituto Nazionale Tumori IRCCS Fondazione Pascale, the study explores how spatial biology — the science of mapping where and how cells interact within tissue — can uncover subtle immune behaviors linked to survival in melanoma patients.
Using Bio-Techne’s COMET platform and a 28-plex multiplex immunofluorescence panel, researchers analyzed 42 pre-treatment biopsies from patients with metastatic melanoma, an advanced stage of skin cancer. Nucleai’s multimodal AI platform integrated these imaging results with pathology and clinical data to trace patterns of immune cell interactions inside tumors.
The findings revealed that therapy sequencing significantly influences immune activity and patient outcomes. Patients who received targeted therapy followed by immunotherapy showed stronger immune activation, marked by higher levels of PD-L1+ CD8 T-cells and ICOS+ CD4 T-cells. Those who began with immunotherapy benefited most when PD-1+ CD8 T-cells engaged closely with PD-L1+ CD4 T-cells along the tumor’s invasive edge. Meanwhile, in patients alternating between targeted and immune treatments, beneficial antigen-presenting cell (APC) and T-cell interactions appeared near tumor margins, whereas macrophage activity in the outer tumor environment pointed to poorer prognosis.
“This study exemplifies how our innovative spatial imaging and analysis workflow can be applied broadly to clinical research to ultimately transform clinical decision-making in immuno-oncology”, said Matt McManus, President of the Diagnostics and Spatial Biology Segment at Bio-Techne.
The collaboration between the two companies underscores how AI and high-plex imaging together can help decode complex biological systems. As Avi Veidman, CEO of Nucleai, explained, “Our multimodal spatial operating system enables integration of high-plex imaging, data and clinical information to identify predictive biomarkers in clinical settings. This collaboration shows how precision medicine products can become more accurate, explainable and differentiated when powered by high-plex spatial proteomics – not limited by low-plex or H&E data alone”.
Dr. Ascierto described the SECOMBIT trial as “a milestone in demonstrating the possible predictive power of spatial biomarkers in patients enrolled in a clinical study”.
The study’s broader message is clear: understanding where immune cells are and how they interact inside a tumor could become just as important as knowing what they are. As AI continues to map these microscopic landscapes, oncology may move closer to genuinely personalized treatment — one patient, and one immune network, at a time.
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From plush figures to digital pets, a new class of AI toys is emerging — built not around screens or sensors, but around memory, language and emotional awareness
Updated
February 5, 2026 2:00 PM
Spielwarenmesse toy fair. PHOTO: SPIELWARENMESSE
Spielwarenmesse in Nuremberg is the global meeting point for the toy industry, where brands and designers preview what will shape how children play and learn next. At this year’s fair, one message stood out clearly: toys are no longer built just to entertain, but to listen, respond and grow with children. Tuya Smart, a global AI cloud platform company, used the event to show how AI-powered toys are turning familiar formats into interactive companions that can talk, react emotionally and adapt over time.
The company’s central argument was simple but far-reaching. The next generation of artificial intelligence toys will not be defined by motors, sensors or screens alone, but by how well they understand human behavior. Instead of being single-function objects, smart toys for children are becoming systems that combine language models, emotion recognition and memory to support ongoing interaction.
One of the most talked-about examples was Tuya Smart’s Nebula Plush AI Toy. At first glance, it looks like a soft, expressive plush figure. Inside, it uses emotional recognition to change its LED facial expressions in real time. If a child sounds sad or excited, the toy’s eyes respond visually. It supports natural conversation, reacts to hugs and touch and combines storytelling, news-style updates and interactive games. Over time, it builds memory, allowing it to behave less like a gadget and more like an interactive AI toy that recalls past interactions.
Another example was Walulu, also developed using Tuya’s AI toy platform. Walulu is an AI pet built around personalization. It can detect up to 19 emotional states and speak more than 60 languages. It connects to major large language models such as ChatGPT, Gemini, DeepSeek, Qwen and Doubao. Through simple app-based controls, users choose traits like cheerful, quiet, curious or thoughtful. Those choices shape how Walulu talks and reacts. Instead of repeating scripts, it adjusts its tone and behavior over time. The result is not a novelty item, but an emotionally responsive AI toy that feels consistent in daily use.
Tuya also showed how educational AI toys can extend into learning and exploration. Its AI Learning Camera blends computer vision with interactive content. When it recognizes an object, it links it to cultural and learning material. If a child points it at a foreign word, it offers real-time pronunciation and translation. It can also turn drawings into digital artwork, encouraging active creativity rather than passive screen time. In this sense, AI toys for kids are becoming tools for learning as much as play.
These products point to a larger strategy. Tuya is not just making toys — it is building the AI toy development platform behind them. Through its AI Toy Solution, developers can design a toy’s personality, memory logic and behavior without training models from scratch. The system integrates with leading AI models and supports multi-turn conversation and emotional feedback, turning standard hardware into responsive AI companions.
The platform supports multiple development paths. Brands can use ready-to-market OEM solutions, add AI to existing products or build custom toys around their own characters. Plush toys, robots, educational tools and wearables can all become AI-powered toys without changing their physical design.
Because these products are made for children and families, safety is built in. Tuya’s system includes parental controls, conversation history review and content management. It supports standards such as GDPR and CCPA with encryption and data localization.
From a business standpoint, Tuya’s pitch is speed and scale. The company says its AI toy infrastructure can cut development time by more than half and reduce R&D costs by up to 50 percent. Its AIoT network spans over 200 countries and supports more than 60 languages, making global deployment of AI toys easier.
What emerged at Spielwarenmesse 2026 was not just a lineup of smart gadgets, but a clear shift in the category. AI toys are evolving into emotionally aware systems that talk, listen, remember and adapt. Their value lies not in sounding clever, but in fitting naturally into everyday life.
The fair did not present AI toys as a distant future. It showed them as products already entering the mainstream. The real question now is not whether toys will use AI, but how carefully that intelligence is designed for children.